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Tuesday, July 21, 2020 | History

3 edition of Voltage-dependent modulation of cardiac calcium channels by dihydropyridines found in the catalog.

Voltage-dependent modulation of cardiac calcium channels by dihydropyridines

Timothy J. Kamp

Voltage-dependent modulation of cardiac calcium channels by dihydropyridines

by Timothy J. Kamp

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  • 9 Currently reading

Published .
Written in English


Edition Notes

Statementby Timothy J. Kamp.
Classifications
LC ClassificationsMicrofilm 88/265 (R)
The Physical Object
FormatMicroform
Paginationxii, 235 leaves.
Number of Pages235
ID Numbers
Open LibraryOL2161327M
LC Control Number88890265

Welcome --Calcium Antagonists and Calcium Agonists: Fundamental Criteria and Classification --With 18 Figures and 5 Tables --Session I: Ca-Channels --Mechanism of Calcium Channel Modulation by Dihydropyridine Agonists and Antagonists --Ca Entry into Vascular Smooth Muscle --Calcium Currents in Mammalian Central Neurones --Session II: Molecular. Homology of Calcium-Modulated Proteins: Their Evolutionary and Functional Relationships.- 1 The Function of the Calcium Channel.- Kinetics, and?-Adrenergic Modulation of Cardiac Ca2+ Channels.- Dihydropyridines, G Proteins, and Calcium Channels.- Electrophysiology of Dihydropyridine Ca .

Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing. Proc Natl Acad Sci USA. ;(38)– Miriyala J, Nguyen T, Yue DT, Colecraft HM. Role of CaVbeta subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV channels. Robert W. Hurley, Steven P. Cohen, in Raj's Practical Management of Pain (Fourth Edition), Calcium Channel Antagonists. Voltage-dependent calcium channel (VDCC) conduction plays an integral role in pain transmission. Diversity among these voltage-gated calcium channels was originally described through differences in the biophysical properties of calcium currents recorded from .

Calcium channel There are two main types of calcium channels: voltage-gated calcium channels, which open in response to changes in membrane potential and ligand-gated calcium channels, which are activated by ligand binding, such as IP 3 receptors, store operated calcium channels . 4-Aryl-l,4-dihydropyridines of the nifedipine type are the most studied class (Fig. ) of organic calcium channel modulators and have been used extensively for the treatment of cardiovascular diseases such as hypertension, cardiac arrythmias or angina.A detailed structure-activity study [] established that calcium channel modulation is dependant on the absolute configuration C4 (R- or S.


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Voltage-dependent modulation of cardiac calcium channels by dihydropyridines by Timothy J. Kamp Download PDF EPUB FB2

Sanguinetti MC, Kass RS ( a) Voltage dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine Ca-channel antagonists. Circ Cited by: 4.

Kass RS, Sanguinetti MC. Inactivation of calcium channel current in the calf cardiac Purkinje fiber. Evidence for voltage- and calcium-mediated mechanisms. J Gen Physiol. Nov; 84 (5)– [PMC free article] Lacerda AE, Brown AM.

Nonmodal gating of cardiac calcium channels as revealed by by: Sanguinetti MC, Kass RS. Regulation of cardiac calcium channel current and contractile activity by the dihydropyridine Bay K is voltage-dependent. J Mol Cell Cardiol.

Jul; 16 (7)– Sanguinetti MC, Krafte DS, Kass RS. Voltage-dependent modulation of Ca channel current in heart cells by Bay KCited by:   The aim of this chapter is to review the methodology needed to investigate the voltage-dependent modulation of L-type calcium-channel activity by dihydropyridine (DHP) derivatives.

Experiments are summarized in which the voltage dependence of channel activity as well as the location of the binding site for dihydropyridines on the L-channel Cited by: 2. Voltage-dependent calcium channels are widely distributed in excitable membranes and are involved in the regulation of many cellular functions.

These channels can be modulated by neurotransmitters and drugs. There is one particular type of calcium channel in cardiac cells (L-type) whose gating is affected in different ways by beta-adrenoceptor and 1,4-dihydropyridine by:   Kass RS.

Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K implications for channel gating. Circ Res. Oct; 61 (4 Pt 2):I1–I5. Kass RS, Arena JP, Chin S.

Block of L-type calcium channels by charged dihydropyridines. Sensitivity to side of application and calcium. Specific binding of a calcium channel activator, [3H]BAY kto membranes from cardiac muscle and brain.

Biochem Biophys Res Commun. May 31; (1)– Kass RS. Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K implications for channel gating. Circ Res. Oct; 61 (4 Pt 2):I1–I5.

Kass RS () Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K implications for channel gating. Circ Res 61 [Suppl 1]:1–5 Google Scholar Kass RS, Arena JP () Influence of pH 0 on calcium channel block by amlodipine, a charged dihydropyridine compound. Modulation of Voltage Dependent Calcium Channels by GABA b Receptors and G Proteins in Cultured Rat Dorsal Root Ganglion Neurons: Relevance to Transmitter Release and Its Modulation Authors Annette C.

Dolphin. Voltage-dependent potentiation of the activity of cardiac L-type calcium channel α 1 subunit due to phosphorylation by cAMP-dependent protein kinase. Proc Natl Acad Sci USA – Google Scholar.

That apparently similar channels in cardiac cells were not affected by chronic depolarization likely indicates structural or regulatory differences between cardiac and neuronal L-type Ca 2+ words: calcium channels, calcium antagonists, 1,4-dihydropyridines, channel regulation, retinal.

Voltage-Dependent Block of Calcium Channel Current in the Calf Cardiac Purkinje Fiber by Dihydropyridine Calcium Channel Antagonists Michael C. Sanguinetti and Robert S. Kass From the University of Rochester, School of Medicine and Dentistry, Department of Physiology, Rochester, New York SUMMARY.

j Mol Cell Cardio, () RAPID COMMUNICATION Regulation of Cardiac Calcium Channel Current and Contractile Activity by the Dihydropyridine Bay K is Voltage-Dependent (Received 18 Januaryaccepted in revised form 27 January ) Pharmacological studies have provided considerable information about the molecu- lar structure of ion channels in the.

Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+) Circ Res. Feb; 64 (2)– Kokubun S, Prod'hom B, Becker C, Porzig H, Reuter H. Studies on Ca channels in intact cardiac cells: voltage-dependent effects and cooperative interactions of dihydropyridine enantiomers.

Mol Pharmacol. Request PDF | Modulation of Calcium Handling: Calcium-Channel Modulators | Several calcium channels (L, N, T, P, Q and R) were identified in humans. Of these channels. Our results suggest that dihydropyridines bind preferentially to the inactivated state of the calcium channel, and that the development of use-dependent block is related to the ionization constants of the compounds.

Furthermore, binding is approximately one thousand times stronger to inactivated channels than to resting channels. These calcium channel blockers (CCB) are selective and inhibit voltage–sensitive L-type slow calcium channels mediated calcium influx in cardiac myocytes and in smooth muscle by slowing the activation of the L-type calcium channel and also delay its recovery from inactivation.

Cyclic AMP-dependent phosphorylation of calcium channels is a likely metabolic step involved in this modulation. Another class of drug that modulates calcium channel gating is the 1,4-dihydropyridines which can either enhance or reduce Ic, either by prolonging the open state of the channels or by facilitating the inactivated state.

The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel. " L" stands for long-lasting referring to the length of activation.

This channel has four subunits (Cav, Cav, Cav, Cav).L-type calcium channels are responsible for the excitation-contraction coupling of skeletal.

Voltage-dependent modulation of Ca channel current in heart cells by Bay K 1,4-dihydropyridines and their potency in cardiac muscle may be due to. Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K implications for channel gating.

Circulation Research. 61 (Suppl I): (). Block of L-type calcium channels by charged l of General Physiology.(). Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+) Circulation Research.

(). Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel .Molecular Characterization of the 1,4-Dihydropyridine Receptor in Skeletal Muscle.- Reconstitution of Solubilized and Purified Dihydropyridine Receptor from Skeletal Muscle Microsomes as Two Single Calcium-Channel Conductances with Different Functional Properties.- 1,4-Dihydropyridines as Modulators of Voltage-Dependent Calcium-Channel Acitivity